Non-Healing Ulcers and Stem Cells

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Fat derived stem cells are an increasing source of cells that have the ability to repair ulcerations from diabetes, radiation induced ulcers, bed sores, and poor circulation says a study published in the Stem Cell Research & Therapy

Treatment with stem cells might be a new treatment option for these patients. Stem cells have the potential to differentiate into numerous types of cells. Over the last decade, stem cell therapy has shown great potential in the treatment of a variety of different conditions, such as orthopedic disorders, inflammatory diseases, hepatic failure, and autoimmune disorders. At the time of writing, adverse events have not been reported; therefore, stem cell treatment is currently regarded as safe. A review including more than 1400 patients found a favorable safety profile of adipose-derived stem cells (ADSC), but also highlighted the poor quality of most studies in regard to registering adverse events.  Better safety data collection can be found at the Cell Surgical Network website in California.

Adipose tissue is an excellent source of autologous ADSC and can be harvested easily compared with bone marrow-derived stem cells (BMSC). Adipose tissue has in recent years surpassed bone marrow as the preferred source of mesenchymal stem cells. Besides being abundant, far easier to harvest, and with a lower risk of complications for the patient, adipose tissue additionally contains about 40 times more stem cells than bone marrow. A simple liposuction of the abdomen or inner thigh performed under local or general anesthesia is sufficient to harvest the required number of ADSC without any significant risk of complications. ADSC can be either freshly isolated or cultured. The culturing takes several days or weeks, and cannot be performed as a same-day procedure nor is culturing available inside the US.  Currently culturing ADSC's is not allowed in the US under federal regulations.  However, with the adipose collection and processing following the procedures outlined by the Cell Surgical Network, culturing may be unnecessary given the high yield of ADSC collected in these facilities across the nation.  For a complete list of facilities that offer this service click here

 

Exosomes - the future of promoting the paracrine effect.

Stem cells are unique cells with amazing healing capabilities, it's only been in the last decade that a substantial number of scientists are investigating and providing insights on how to use them most effectively with the help of clinicians having "boots on the ground" actually witnessing the effects and what they're capable of.  As well as what concurrent therapies or interventions might increase the stem cells ability to work their magic.

Here is were exosomes come in.  Science has recently discovered what actually happens when the endogenous stem cells are deployed in a body joint, or spine.  It appears that it's the presence of the stem cells that's most important, not the idea that they just repair damage but that they have a unique signaling system, the "paracrine effect".  This is the cell to cell communication that goes on once the stem cells are implanted.  One of the most important talking, or signalling messengers molecules are exosomes excreted from the stem cells to the surrounding cells and tissues encouraging them to repair and regenerate.  through a complicated process of angiogenesis (formation of new blood vessels) and tissue renewal they appear to be able to improve the promotion of the stem cells.

Although exosomes were discovered over five decades ago, interest among the scientific community didn’t pique until much later.  Specifically, in the last ten years, the number of annual publications about exosomes have almost increased by tenfold (from 1,570 published papers in 2007 to 14,000 in 2017).   

How to BOOST your own stem cell production

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I'm often asked, "What can I do nutritionally to increase my chances of success with my stem cell procedure?"  This has lead me down some interesting paths of research over the years and one technique continues to outshine the others, by a long shot.  And honestly, I've only had 2 patients take me up on it.  It is FASTING, in fact a 5 day water fast, ouch... I know you didn't want to hear it, nobody does.  Just the thought makes people cringe.  Knowing instantly that they can't conceive of that kind of self torture, and instantly decide - nope, not going to happen.

Here's the good part.  It's really not that hard, once you get passed  the first 48 hours the rest is a breeze, kinda.  It's still hard but the rewards are indisputable given all the research that surrounds this age old therapy.  Utilized over the ages by all the great physicians.  In fact, On October 3, 2016, the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for “discoveries of the mechanisms for autophagy.”  The reason it works says Omer Yilmaz, an MIT professor of biology, a member of the Koch Institute for Integrative Cancer Research, is that fasting invokes all the restorative components of the body while eating up and destroying dead cells, dying cells and genetically damaged cells in a process called autophagy. Google it, or click the links above.

Even better.  There are much less dramatic ways to induce the same autophagy without the extreme 5 day water fast.  It's called intermittent fasting.  This is when you go several hours between meals, and the farther apart the meals the better.  An example, eating your last meal at 7pm and then skipping breakfast (no it's not the most important meal of the day) and waiting until early afternoon before your next meal, say at 2pm.  This creates a 5 hour eating window for you to get in the calories you need while invoking the autophagy principle in the prior 19 hours of fasting.  Sure, the autophagy works better the longer you go without food, but for those who just can't imagine going a whole day without something, or perhaps for other medical reasons such as not taking your meds on an empty stomach.  Then this method may be just what the doctor ordered.

Feel free to comment below.  Would love to hear your experiences.

 

Adult or youth stem cells best?

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A common question patients have when inquiring about stem cell therapy is whether or not their stem cells are still any good?  This is a very good question when your 78 years old and thinking your cells are too old to regenerate.  The industry standard is to use a common sense opinion and say well, yes... if your older then your stem cells are older and less viable, less enthusiastic, less capable.  But, a recently published paper in the Frontiers in Cardiovascular Medicine may change that opinion.  When cells are harvested from an elderly patient and then through an new process converted back to a pluripotent stem cell (iPSC), they appear to be as viable, as enthusiastic and capable as that of an embryo.  That's amazing.

Dr Charles Nemeroff "You infuse these cells, and they literally go to the hot spots, your knee, your chest."

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Dr. Charles Nemeroff, Director of the University of Miami Center on Aging and Chairman of the Department of Psychiatry and Behavioral Sciences at University of Miami, Speaking about the use of mesenchymal stem cells intravenously administered.  As described in his interview with Psychiatric Times. He touched on a variety of subjects related to depression, in addition he lauded the benefits of intravenously administered stem cells as he has witnessed for patients.  Although it is not condoned by the FDA, FDA Chairman Dr Gottlieb has agreed to not interfere with offices that adhere to good, sterile procedures for the next 3 years at which time it is anticipated that this practice will be legally considered a "drug" therapy.  This would mean that the same rigorous rules applied to a new drug would also be applied to stem cell therapy.  However, given that drug companies can not patent this procedure (it's an all natural procedure), they really can't make any money here which means no money to pay for the rigorous and extremely expensive laboratory testing.  Being in the 100's of millions of dollars it is unlikely any local clinic will be funding it.  It will likely mean leaving the US in order to use your own cells to heal yourself.  It is no doubt the drug companies pressure on the FDA that will likely win in the courts.

We can't have people side stepping the pharmacy and healing themselves now can we, that would be horrible - insert huge sarcasm here.

Although stem cell therapy is still evolving, the next ten years are going to be exciting. With billionaires getting older, you watch... they're dumping their own money into biotech to find the fountain of youth.  Follow the link below:

So... it may not be the weight after all that's wrecking your knees?

Could the extra weight that most Americans are carrying around just be inconsequential to their knees wearing out prematurely?  Remembering, correlation does not imply causation.  Meaning, maybe the extra weight really has nothing to do with those bad knees?  The gut microbiome is once again suspect in another condition, osteoarthritis.  This isn't new, I've been reading about and experiencing this with daily patient interaction for years.  Your gut bacteria have a lot to say about your general inflammatory markers, or the degree at which your body maintains a constant low grade inflammatory condition.  The end result - osteoarthritis, atherosclerosis, autoimmune, degenerative joint disease, etc...

The solution - better diet, exercise, stay healthy, sleep... easy right?  Nope, in fact getting regular exercise, adequate sleep, a healthy diet and positive view of the future and life in general is one of the most challenging aspects of the human condition.  But you can do it!

Never underestimate the importance of motion palpation

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Over the years I have personally witnessed time and time again a misdiagnosis.  The classic case is the individual with said "hip pain" and diagnosed with degenerative osteoarthritis of the hip as seen on an x-ray/MRI and the recommendation of complete hip replacement.  I have learned to never take that diagnosis at face value.  More often than I can count, after a complete physical examination I find the real culprit to be the lower spine, facet damage, bursitis or one of the sacroiliac joints.  Yes, they may indeed have some degenerative OA of the hip but if that's not causing the pain, then what good is it to perform a total hip replacement only to observe the patient when the surgery is complete and the pain remains!

This phenomenon can easily be related to any other joint in the body as well.  I'm always shocked after the exam when a patient remarks, "Why didn't my doctor do that?" and I say, "Do what?" "You felt around and moved me around in different positions until you found my problem, my doctor never touched me." Wow, just wow.

 I don't understand the omission of the physical exam by many doctors.  Getting a second opinion is always a good idea when something like spine surgery or a total joint replacement is recommended.  And with the advancements of today, options like stem cell therapy is proving to be a major game changer and making the spine surgery/joint replacement folks very nervous.  Don't get me wrong, joint replacement surgery will never go away as there are times when it is completely necessary.  But, necessary is becoming less and less common.

Stem cell transplant 'game changer' for MS patients

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You may be familiar with "bone marrow transplant", it's been a regular practice in medicine since the 50's.  But did you know in reality this is a stem cell transplant?  In this article you'll hear of the amazing results they are getting with stem cell transplant.  What you may not know is that this is available in the U.S.  The only difference in our office is that we do not chemically destroy your immune system.  we instead simply infuse your stem cells intravenously every 3 months over the course of the year up to two years.  In this way we are able to avoid the very dangerous practice of decimating your immune system with chemotherapy drugs, while still giving your stem cells an opportunity to "reset" your immune system.  The idea is to "reset" or "reboot" your immune system so as to stop attacking your nervous system which is the cause of the symptoms associated with MS.

Are all stem cell clinics the same?

With the explosion of stem cell clinics across the globe over the last few years, combined with limited resources from regulatory agencies both foreign and domestic. How do you know if you're dealing with the real deal?

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it is completely possible to start a stem cell clinic doing everything right from the start and do excellent work and help people tremendously. It is also possible to cut corners, use known bogus amniotic fluid or placental stem cells to make a quick buck, fill the coffers full of gold until word gets out, then off to the next unassuming town.  It's happening all around the country making a bad name for those who are using sound science behind their operation.  It's very inexpensive to get a bogus clinic up and running, it's VERY expensive to get a legitimate clinic up and running. Physicians aren't cheap, the tools of the trade aren't cheap.  The guided imaging tools aren't cheap.   So, there's one good clue. Do they have 200k+ invested in imaging? Look around, take a tour of the office and observe, if it looks really expensive it usually is. Do they have a 100k+ invested in their in-office lab?  Just ask to see their lab. Do they have a physician\medical officer? If they have these 3 things their is a good chance they're doing things right and you can be optimistic about your results. Of course with any medical practice there's little substitution for experience. Do they have lots of happy patients that refer to that office? For more information or need some helpful guidance feel free to contact me. I'm very passionate about this work and want to see it protected from corruption. 

www.mystemcellusa.com

MS sufferers get renewed hope with stem cells

Several trials continue to show real results with MS. And not just temporary relief but actual cure. It would be fantastic to see this as the approved treatment for MS as well as several other autoimmune conditions such as Lupus, Psoriasis, Rheumatoid arthritis, etc.

Follow the link for more information on the most recent study from Time magazine.  

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No Tamaflu? No Problem - why take a drug when you've got...

Tamaflu

Move over...

take Tamaflu and you could get...

  • nausea,
  • vomiting,
  • diarrhea,
  • dizziness,
  • headache,
  • nosebleed,
  • eye redness or discomfort,
  • sleep problems (insomnia), or
  • cough or other respiratory problems.

These and other negative side effects are possible when taking this prescription drug.  A whole lot better idea is to take Quercetin.  

As described by Byron J. Richards, Board Certified Clinical Nutritionist.  Quercetin is as effective without the side effects!  Wow, did you know that?

And further, Dr Mercola also goes into great depth in explaining the benefits of Quercetin here.

So, the next time you hear on the local news there's a shortage of Tamaflu, just remember that is designed intentionally to rally the troops to demand more Tamaflu!  The Feds and State health departments will get pressure from well meaning citizens to demand that we be prepared for next flu season by spending your tax dollars in the 100's of millions to stockpile Tamaflu!  Save the war-cry and just get Quercetin.

"No added sugar for me please" more and more evidence indicating "type 3 diabetes" as the cause of Alzheimer's

Evidence to support the idea of a "type 3 diabetes" continues to gain traction as the cause of Alzheimer's disease.  Multiple studies now lead scientists to confirm this connection.  

Another reason to go low carb (as if you needed another one)

Maintaining low blood sugar is associated with an increase in circulating stem cells.  To achieve this you need to maintain high insulin sensitivity.  When cells of the body become insensitive to circulating insulin your blood sugar can elevate and remain elevated throughout the whole day.  Stem cells are your bodies circulating signaling cells to heal and regenerate injured or sick tissues.  A decrease in these cells is associated with accelerated aging and osteoarthritis and other degenerative diseases.  To reference the article click here

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Still waking up to an alarm clock?

There's a better way to wake up!  How many times have you heard your alarm clock going off and immediately had some negative thoughts.  Or, it's going off and you fumbling around looking for the snooze on your phone, you knock it off onto the floor, you try to ignore the buzzer and pull the covers over your head and try to get in a few extra winks.  There's a better way.

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