The most difficult traumatic brain injuries (TBI) to treat successfully are the individuals who have had their injury several months or worse, years earlier. The typical response to an injury of the brain is scar tissue and other connective tissues that do not resemble normal brain matter.
One progressive method is to introduce stem cells, either bone marrow stem cells (BMSC), adipose stem cells (ADSC), or umbilical cord stem cells (UCSC) into the intrathecal space (the area just outside the spinal cord, within the sheath that covers the spinal cord). This is the space that contains the cerebral spinal fluid (CSF). This attempt was a natural choice as it was widely accepted early on that stem cells do not cross the blood brain barrier (BBB). More recent evidence suggest that they actually do, just not efficiently it does require some migration of the stem cells to get across the BBB.
More recently it has been accepted that it is not the injected stem cells that are differentiating into the new nerve tissue, rather the presence of the stem cell activates the cells around them to become active. Further, the stem cells release messenger molecules that up regulate the brain tissue to grow and repair, not in an uncoordinated random way, but in a very controlled regenerative process that repairs brain matter. The challenge has been, how to get the stem cells to the areas of the brain that need them the most?
Observation of dozens of cases of TBI improvement with ADSC deployment intravenously had been recorded. How did the stem cells find their way to the brain? Stem cells migrate. They have amoeba and immune cell type mobility. They can migrate to the area of dysfunction and begin the repair process. In addition, the exosomes secreted by the stem cells are very small, between 80 - 250 nano-meters. That's small. Small enough to cross the BBB with ease, therefore it is postulated the regenerative process of the brain is likely more do to the influx of exosomes in the presence of stem cells that's making the difference. And in fact, we recommend an iv push of exosomes produced by young umbilical stem cells at the same time as the ADSC are deployed/infused.
What's more, I have a unique slant on the process that can significantly increase the likelihood of recovery. We know coffee has a unique ability to decrease blood flow to the brain, which is why if you suddenly discontinue regular coffee use, an individual can get a bad headache as the blood comes rushing back to the brain causing swelling. Utilizing this reaction, drink 3-4 cups of coffee each morning for a month leading up to the procedure. Have your last meal 48 hours prior to the procedure. Have your coffee the morning of the procedure, then discontinue all together until a raging migraine appears, naturally this is very uncomfortable for about 48 hours until the blood flow can regulate itself at which time the headache will disappear. It is during this headache when the stem cells will quickly migrate to the brain as well as increased secretion of exosomes and other extracellular vesicles.
Lastly, fasting for 48 hours prior to the procedure will also induce autophagy, increase natural stem cell production and activation when we harvest them from the mini-liposuction procedure.
Let me know if you have any questions or comments.