Don't get a steroid shot in your knee! Here's why...


Below details the result of a study looking at repeated steroid shots for knee pain - The conclusion? It will wear out your knee faster than if you just left it alone. Repeated steroid injections only furthers the likelihood that you’ll need a much more invasive procedure later.

Better yet… Stem Cell injections into the knee can repair the knee and avoid knee surgery all-together :)

Osteoarthritis Cartilage. 2019 Jan 29. pii: S1063-4584(19)30033-0. doi: 10.1016/j.joca.2019.01.007. [Epub ahead of print]

Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative.

Zeng C1, Lane NE2, Hunter DJ3, Wei J4, Choi HK5, McAlindon TE6, Li H7, Lu N8, Lei G9, Zhang Y10.

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A recent randomized clinical trial reported that repeated intra-articular corticosteroids (IACs) were associated with a greater cartilage loss. This study aimed to examine the relation of IACs to knee radiographic osteoarthritis (ROA) progression in a real-world setting.


A cohort that initiated IACs and a comparison cohort without IACs from participants with mild to moderate knee ROA in the Osteoarthritis Initiative (OAI) were assembled (from 0-month to 48-month). Two measures of knee ROA progression were assessed during the follow-up period: (1) an increase in Kellgren and Lawrence (KL) grade by ≥1 grade or having a knee replacement (i.e., KL grade worsening); and (2) a decrease in joint space width (JSW) by ≥0.7 mm or having a knee replacement (i.e., JSW worsening). The associations of IACs initiation using a propensity-score matched cohort study and continuous IACs using marginal structural models with the risk of knee ROA progression were examined.


Among 684 propensity-score matched participants at baseline (148 IACs initiators, 536 comparators), 65 knees (21.7/100 person-years) in the IACs initiation cohort and 90 knees (7.1/100 person-years) in the comparison cohort experienced KL worsening. The hazard ratios (HRs) of KL worsening from IACs initiation and continuous IACs were 3.02 (95% confidence interval [CI], 2.19-4.16) and 4.67 (95% CI, 2.92-7.47), respectively. The corresponding HRs of JSW worsening were 2.93 (95% CI, 2.13-4.02) and 3.26 (95% CI, 1.78-5.96), respectively. All HRs for continuous use of IACs were further away from the null.


IACs, especially continuous IACs, may be associated with an increased risk of knee ROA progression.

Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.


Cohort; Corticosteroids; Osteoarthritis; Progression

PMID: 30703543 DOI: 10.1016/j.joca.2019.01.007