regenerative medicine

Crohn's disease patients effectively mobilize peripheral blood stem cells to perform autologous haematopoietic stem cell transplantation

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Crohn's disease is a very horrible condition of the intestines.  It's can make any errand away from home a stressful and often embarrassing endeavor.  Also, for most it can be very painful and gut wrenching.  Several types of food can be very unpleasant.  During flares, life can be downright miserable.  

It's encouraging to see that stem cell therapy is gaining favor in light of several new reports showing promise, and even better than pharmaceutical drugs that can cost over $10,000 a month.  Even more encouraging, there are stem cell resources in the body that can treat the underlying cause of Crohn's disease.  Stromal vascular fraction is recovered by processing fat tissue after a mini-liposuction procedure that is very non-invasive and takes about 30min.  After, the fat is off to process in the lab.  And then an hour later the cells are ready to be administered through iv for about 45min.  The stromal vascular fraction (SVF) has remarkable attributes.  The stem cells and extracellular vesicles are able to down regulate immune cells through a series of cell-to-cell communications.  

The adipose (fat) tissue stem cells seem to be especially gifted in their ability to modulate the immune system in a beneficial way.  And not just to benefit Crohn's, but a whole host of immune system dysfunctions.  

This is so encouraging for those who suffer with immune system problems.  A cure is on the way and it's looking like it's going to happen.  I do believe in the near future this will be a very common procedure to cure autoimmune diseases.

In search of the Holy Grail of Healing - Part 1

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It has been my lifelong journey to find the fountain of youth.  I've spent the last 25+ years exploring natural healing and regeneration.  I came up wanting every time.  Spent thousands of hours, thousands of dollars exploring and researching trending stories, tropical berries, rare earth gases, ionizing waters, vitamin regimens, spinal manipulative techniques, chi activation, functional medicine, meditation and the list goes on.  The pursuit has always been to activate and or release the innate regenerative properties of the body, similar to a time when it was not ever a thought.  You know, like you did when you were twelve.  The ability to heal with great enthusiasm fades as we age, and it's heart breaking.  Just as we transition to a time when we have more time, the so called "golden years" we seem to be instead of ramping up our exploration of this world we are besieged by an onslaught of debilitating illnesses, aches, pains, moans and groans.  

How is it that along our path our bodies decided, without consultation by the way, to fall into a state of not only disrepair but into the lion's den of medical miss-information in the guise of science.  Science, as I have learned is malleable, plastic, persuasive and even deceitful when in the hands of financial concerns of shareholders.  Why is it that you go to the doctors with a belly ache and multiple vials of blood, a CT and Ultrasound and $2,000 later you're told there's nothing wrong with you and you have a stomach virus, instructed to go home and take the medications, rest and everything will be fine - "Thanks for doing business with us!" is what they should say, because that's what you did, you did business with them.

Every century or so a discovery is found that changes everything.  We see a "paradigm shift".  Something is discovered that changes everything, it refocuses the entire science and medical community in a new direction.  This is occurring as I write this letter.  Just think "biotech", how's the biotech industry?  It's BOOM city.  Billions are flowing into the new biology of healing with the re-discovery of cell biology and innate healing.  The science of regenerative medicine is exploding and heading to your town despite the criticism of old hard-liners who do not want anything to change because they are very comfortable doing things just the way things always have been done.  

Change is uncomfortable and requires learning, study and re-tooling.  Those who re-tool and learn what the cell biologists are bringing to light are the early pioneers in regenerative medicine.  Specifically I'm talking about cell therapy.  But more precisely, stromal vascular fraction (SVF).   It is the SVF that is the stuff of legends, teaming with stem cells, progenitor cells, growth factors, cytokines, exosomes, etc.  This stroma is of natural origin, it comes from you within the adipose tissue.  Yes, I mean your fat!  As it turns out your fat is absolutely an amazing organ - and yes it's considered an organ by many biologists.  Strangely enough, it was really the frequent discovery by plastic surgeons that fat is an amazing substance to work with. The fat tissues throughout your body has some amazing properties.  I wont bore you with the details however, feel free to research SVF on you own on the PubMed website, research is no longer the privilege of the educated but is available to anyone willing to put in the time.

The physician's office today producing SVF from the tissues of the patient are wielding an amazing regenerative tool in the fight against damaged, dying and decaying tissues in the body.  It can be deployed (injected) into damaged tissues, it can be deployed intravenously for systemic disease conditions, auto-immune conditions, traumatic brain injury and on and on.  In the near future you will not be given a pill, you'll be deploying your cells.  But here's the kicker.  It's going to be kept out of the hands of your local mainstream medical clinics and hospitals.  Why, if it's so great?  Because, if you think about it, these are YOUR cells.  Not a medication, not a synthetic chemical, not titanium hardware, not another million dollar body scanner.  Can you begin to see why this new paradigm is going to struggle to get to the surface?  Billions are being poured into research by big pharma to find a cell therapy that can be synthesized, bottled and given a lengthy expiration date to be put on the shelf for sale.  Sorry, but you can't synthesize the bodies innate healing powers, it's not reproducible.  It can only be deployed appropriately.  Not to be duplicated.

It's an exciting time to be a pioneer in the field of regenerative medicine and I'm having the best time of my life exploring what is possible.  I see the difference it makes in the lives of those we serve.  I cheer the scientists and biologists who continue to advance this field in the face of heavy criticism of big pharma's influence throughout the medical community and mass media who have billions upon billions at stake.  

Heart Patients can breathe a sigh of relief

The stem cells and other progenitor cells concentrated as SVF or Stromal Vascular Fraction from the patients fat after a mini-liposuction has the potential to radically alter the way patients are treated following a heart attack, stroke, angina, or heart failure.  Other attempts at stem cell therapy have also shown to be beneficial as well.  But the greatest concentration of these regenerative cells and stem cells are found in the fat derived stromal vascular fraction. 

Experts say initial findings suggest those who have suffered crippling heart failure can go on to lead normal lives.

Dr John Hung, a cardiology specialist working on the trials in Edinburgh, said that because anyone can have the treatment it has the potential to save huge numbers of lives and at the same time slash the NHS bill for the future care of heart failure patients.

He added: “We think about one in five people who survive a major heart attack are likely to benefit from the therapy, and this could mean hundreds of thousands in the UK or many millions across the world.

"There should also be healthcare savings from the reduced costs for medication, ongoing treatment and recurrent hospitalisations.”

One patient who was given a 50-50 chance of surviving five years after suffering a major heart attack, because of the damage it caused, has spoken of his gratitude of being given the radical treatment.

One patient called Bill, not his real name, now has almost normal heart function and he believes he has been given a second chance at life.

We are now offering this life saving therapy in our Seattle and Salt Lake locations.  Contact us soon to see what we can do for you or a loved one.

Stem Cell for Traumatic Brain Injury (TBI)

Once again we are seeing incredible progress with the iv administration of adipose (fat) derived stem cell on the recovery of brain injury, such as in stroke, trauma, lack of oxygen, or heart attack.  Most recently an 11 year old who suffered cardiac arrest after a freak accident involving a pellet gun that misfired and logged a pellet in his heart.

Although he survived the ordeal, he was left with considerable brain injury.  However, fortunately they were alerted to a stem cell facility outside the US that had the capability to extract stem cells from the boy's fat.  The cells are then culture expanded to create hundreds of millions of cells to then administer them through an iv.  

What most people are unaware is that this process can be performed here in the US.  In fact, here in Salt Lake City were are performing this very procedure.  The only difference is that we do not need to culture the cells.  In our proprietary cell processing, as performed in all Cell Surgical approved locations, we are able to not only concentrate the stem cells, but also the other related cells, cytokines, growth factors and adipocytes that are crucial to healing and repair.

We stand in bewilderment of the innate power of the body, it is only now that we are learning ways to work with it to optimize the regenerative powers of the body.  These are glorious times.

Non-Healing Ulcers and Stem Cells

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Fat derived stem cells are an increasing source of cells that have the ability to repair ulcerations from diabetes, radiation induced ulcers, bed sores, and poor circulation says a study published in the Stem Cell Research & Therapy

Treatment with stem cells might be a new treatment option for these patients. Stem cells have the potential to differentiate into numerous types of cells. Over the last decade, stem cell therapy has shown great potential in the treatment of a variety of different conditions, such as orthopedic disorders, inflammatory diseases, hepatic failure, and autoimmune disorders. At the time of writing, adverse events have not been reported; therefore, stem cell treatment is currently regarded as safe. A review including more than 1400 patients found a favorable safety profile of adipose-derived stem cells (ADSC), but also highlighted the poor quality of most studies in regard to registering adverse events.  Better safety data collection can be found at the Cell Surgical Network website in California.

Adipose tissue is an excellent source of autologous ADSC and can be harvested easily compared with bone marrow-derived stem cells (BMSC). Adipose tissue has in recent years surpassed bone marrow as the preferred source of mesenchymal stem cells. Besides being abundant, far easier to harvest, and with a lower risk of complications for the patient, adipose tissue additionally contains about 40 times more stem cells than bone marrow. A simple liposuction of the abdomen or inner thigh performed under local or general anesthesia is sufficient to harvest the required number of ADSC without any significant risk of complications. ADSC can be either freshly isolated or cultured. The culturing takes several days or weeks, and cannot be performed as a same-day procedure nor is culturing available inside the US.  Currently culturing ADSC's is not allowed in the US under federal regulations.  However, with the adipose collection and processing following the procedures outlined by the Cell Surgical Network, culturing may be unnecessary given the high yield of ADSC collected in these facilities across the nation.  For a complete list of facilities that offer this service click here

 

How to BOOST your own stem cell production

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I'm often asked, "What can I do nutritionally to increase my chances of success with my stem cell procedure?"  This has lead me down some interesting paths of research over the years and one technique continues to outshine the others, by a long shot.  And honestly, I've only had 2 patients take me up on it.  It is FASTING, in fact a 5 day water fast, ouch... I know you didn't want to hear it, nobody does.  Just the thought makes people cringe.  Knowing instantly that they can't conceive of that kind of self torture, and instantly decide - nope, not going to happen.

Here's the good part.  It's really not that hard, once you get passed  the first 48 hours the rest is a breeze, kinda.  It's still hard but the rewards are indisputable given all the research that surrounds this age old therapy.  Utilized over the ages by all the great physicians.  In fact, On October 3, 2016, the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for “discoveries of the mechanisms for autophagy.”  The reason it works says Omer Yilmaz, an MIT professor of biology, a member of the Koch Institute for Integrative Cancer Research, is that fasting invokes all the restorative components of the body while eating up and destroying dead cells, dying cells and genetically damaged cells in a process called autophagy. Google it, or click the links above.

Even better.  There are much less dramatic ways to induce the same autophagy without the extreme 5 day water fast.  It's called intermittent fasting.  This is when you go several hours between meals, and the farther apart the meals the better.  An example, eating your last meal at 7pm and then skipping breakfast (no it's not the most important meal of the day) and waiting until early afternoon before your next meal, say at 2pm.  This creates a 5 hour eating window for you to get in the calories you need while invoking the autophagy principle in the prior 19 hours of fasting.  Sure, the autophagy works better the longer you go without food, but for those who just can't imagine going a whole day without something, or perhaps for other medical reasons such as not taking your meds on an empty stomach.  Then this method may be just what the doctor ordered.

Feel free to comment below.  Would love to hear your experiences.

 

So... it may not be the weight after all that's wrecking your knees?

Could the extra weight that most Americans are carrying around just be inconsequential to their knees wearing out prematurely?  Remembering, correlation does not imply causation.  Meaning, maybe the extra weight really has nothing to do with those bad knees?  The gut microbiome is once again suspect in another condition, osteoarthritis.  This isn't new, I've been reading about and experiencing this with daily patient interaction for years.  Your gut bacteria have a lot to say about your general inflammatory markers, or the degree at which your body maintains a constant low grade inflammatory condition.  The end result - osteoarthritis, atherosclerosis, autoimmune, degenerative joint disease, etc...

The solution - better diet, exercise, stay healthy, sleep... easy right?  Nope, in fact getting regular exercise, adequate sleep, a healthy diet and positive view of the future and life in general is one of the most challenging aspects of the human condition.  But you can do it!

Never underestimate the importance of motion palpation

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Over the years I have personally witnessed time and time again a misdiagnosis.  The classic case is the individual with said "hip pain" and diagnosed with degenerative osteoarthritis of the hip as seen on an x-ray/MRI and the recommendation of complete hip replacement.  I have learned to never take that diagnosis at face value.  More often than I can count, after a complete physical examination I find the real culprit to be the lower spine, facet damage, bursitis or one of the sacroiliac joints.  Yes, they may indeed have some degenerative OA of the hip but if that's not causing the pain, then what good is it to perform a total hip replacement only to observe the patient when the surgery is complete and the pain remains!

This phenomenon can easily be related to any other joint in the body as well.  I'm always shocked after the exam when a patient remarks, "Why didn't my doctor do that?" and I say, "Do what?" "You felt around and moved me around in different positions until you found my problem, my doctor never touched me." Wow, just wow.

 I don't understand the omission of the physical exam by many doctors.  Getting a second opinion is always a good idea when something like spine surgery or a total joint replacement is recommended.  And with the advancements of today, options like stem cell therapy is proving to be a major game changer and making the spine surgery/joint replacement folks very nervous.  Don't get me wrong, joint replacement surgery will never go away as there are times when it is completely necessary.  But, necessary is becoming less and less common.